Angelika Doetzlhofer, Ph.D.

Assistant Professor of Neuroscience

The Solomon H. Snyder Department of Neuroscience
Johns Hopkins University
School of Medicine
855 North Wolfe St.
Baltimore, MD 21205

Room: 433 Rangos

Telephone: (410) 614-9215
Fax: (443) 287-7672

Email: adoetzlhofer@jhmi.edu

 

Research summary

A main goal of Dr. Doetzlhofer’s laboratory is to identify and characterize the molecular mechanisms of hair cell development in the mammalian auditory system. She would also like  to identify the molecular roadblocks preventing mammalian hair cell regeneration. In mammals, hair cell generation is limited to embryonic development. Lost hair cells are not replaced leading to deafness and balance disorders. However, in non-mammalian vertebrates, supporting cells undergo a process of de-differentiation after hair cell loss, and are able to replace lost hair cells by either cell division or direct trans-differentiation. Her experiments suggest that the lack of mammalian hair cell regeneration is likely due to an absence or blockage of regenerative signals.

Doetzhofer Lab