Paul Fuchs, Ph.D.

John E. Bordley Professor of Otolaryngology- Head and Neck Surgery

Johns Hopkins University
School of Medicine
Department of Otolaryngology, Head and Neck Surgery
Baltimore, MD 21205
Room: 818 Ross Bldg.

Telephone: (410) 955-6311
Fax: (410) 614-4748

Emailpfuchs1@jhmi.edu

 

Research summary

The Fuchs laboratory uses cellular electrophysiology, immunolabeling and electron microscopy to study synaptic connections between sensory hair cells and neurons in the cochlea.  One effort focuses on an unusual cholinergic receptor that mediates efferent inhibition of hair cells, driving discovery of the molecular mechanisms, and offering a target for protection against acoustic trauma.  A second topic concerns the small number of unmyelinated ‘type II’ afferent neurons whose synaptic connectivity and response properties argue for a role as the pathway for noxious (too loud) sound.   Our studies are motivated by curiosity about fundamental mechanisms, and to provide a foundation for understanding cochlear pathogenesis.

Links

Fuchs Lab